GutBrain Clinical Protocol • Consolidated Guide
The SIBO & MCAS Connection: Rebuilding the Gut Ecosystem Without Triggering Histamine Flares
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4-Stage Clinical Sequencing Summary
- Stage 1 — Mucosal Mast Cell Shielding: Stabilize subepithelial mast cells (Quercetin Phytosome, PEA, luminal DAO) before antimicrobial or probiotic shifts.
- Stage 2 — Mechanical Sweeping & Phase III MMC Restoration: 12–14h interdigestive fasting windows + nocturnal prokinetics to clear small-bowel stasis.
- Stage 3 — Low-Histamine Keystone Repopulation: Targeted Limosilactobacillus reuteri (ATCC PTA 6475 & DSM 17938) for upper-GI reuterin defense without biogenic histamine overload.
- Stage 4 — Non-Fermentable Mucosal Sealing: L-Glutamine, Zinc Carnosine, and glycine/proline scaffolding to restore ZO-1 and Claudin-1 tight junctions.